Wednesday, March 10, 2010

New Study Involving Longvida Curcumin . . . Namely SLCP

A new study was published using the SLCP formula that Longvida Curcumin is made with. Very good results were achieved in the study (note bolded parts).

Safety and pharmacokinetics of a solid lipid curcumin particle formulation in osteosarcoma patients and healthy volunteers.

Gota VS, Maru GB, Soni TG, Gandhi TR, Kochar N, Agarwal MG.

ACTREC, Tata Memorial Centre, Sector-22, Kharghar, Navi Mumbai 410210, India. vgota@actrec.gov.in

Curcumin is the lipid-soluble antioxidant compound obtained from the rhizome of Curcuma longa Linn, also known as turmeric. Curcumin targets multiple chemotherapeutic and inflammatory pathways and has demonstrated safety and tolerability in humans, supporting its potential as a therapeutic agent; however, the clinical literature lacks conclusive evidence supporting its use as a therapeutic agent due to its low bioavailability in humans. The purpose of this study was to quantify plasma levels of free curcumin after dosing of a solid lipid curcumin particle (SLCP) formulation versus unformulated curcumin in healthy volunteers and to determine its tolerability and dose-plasma concentration relationship in late-stage osteosarcoma patients. Doses of 2, 3, and 4 g of SLCP were evaluated in 11 patients with osteosarcoma. Plasma curcumin levels were measured using a validated high-performance liquid chromatography method. The limit of detection of the assay was 1 ng/mL of curcumin. In healthy subjects, the mean peak concentration of curcumin achieved from dosing 650 mg of SLCP was 22.43 ng/mL, whereas plasma curcumin from dosing an equal quantity of unformulated 95% curcuminoids extract was not detected. In both healthy individuals and osteosarcoma patients, high interindividual variability in pharmacokinetics and nonlinear dose dependency was observed, suggesting potentially complex absorption kinetics. Overall, good tolerability was noted in both healthy and osteosarcoma groups.

PMID: 20092313 [PubMed - in process]

I've requested a copy of the full text of this study too, so we'll see if that may show anything else interesting.

Qadoshyah

1 comments:

Liora P said...

hi, Q, there is a newer study (2012) that is available in full text that looks at Longvida being superbly bioavailable. http://www.mdpi.com/1999-4923/4/4/517/htm

also related:
http://www.sciencedirect.com/science/article/pii/S1756464615000493

and
http://blog.naturalpartners.com/solid-lipid-curcumin-particle-slcp-shows-improvement-in-cognition-and-mood-in-healthy-older-population-in-an-rct/

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