Wednesday, October 24, 2007

Turmeric helping AD again!

I read about the following abstract in LEF's newest magazine. I thought it was pretty interesting. Basically it is saying that by giving these people with AD curcuminoids (the active ingredient in Turmeric) that it increased the absorption of amyloid-beta (which is a good thing). AB creates plaques and tangles in the brain and that is part of the problem in AD. The curcuminoids helped strengthen the immune system of these people to be able to deal with the AB.
Curcuminoids enhance amyloid-β uptake by macrophages of Alzheimer's disease patients

Laura Zhang A1, Milan Fiala A1, John Cashman A2, James Sayre A3, Araceli Espinosa A4, Michelle Mahanian A1, Justin Zaghi A1, Vladimir Badmaev A5, Michael C. Graves A6, George Bernard A4 A7, Mark Rosenthal A1


Treatment of Alzheimer's disease (AD) is difficult due to ignorance of its pathogenesis. AD patients have defects in phagocytosis of amyloid-β (1-42) (Aβ) in vitro by the innate immune cells, monocyte/macrophages and in clearance of Aβ plaques [5]. The natural product curcuminoids enhanced brain clearance of Aβ in animal models. We, therefore, treated macrophages of six AD patients and 3 controls by curcuminoids in vitro and measured Aβ uptake using fluorescence and confocal microscopy. At baseline, the intensity of Aβ uptake by AD macrophages was significantly lower in comparison to control macrophages and involved surface binding but no intracellular uptake. After treatment of macrophages with curcuminoids, Aβ uptake by macrophages of three of the six AD patients was significantly (P<0.001>

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